Biomedica Haemostasis

A complete line of specialty coagulation and diagnostic products, focused on haemostasis & thrombosis diagnostic solutions for human and animal health

Antibodies & Proteins

Anticoagulant Therapy

Antiphospholipid Syndrome

Bleeding Profiles

Cancer Prognosis

Chromogenic & Fluorogenic Substrates

Controls & Calibrators

D-dimer

Thrombotic Risk Markers

Thrombotic Thrombocytopenia Purpura

Von Willebrand Disease

Anticoagulant Therapy
ACTICHROME® Heparin (Anti-FIIa), Activity Assay REF: 820 is an amidolytic chromogenic assay intended for the quantitative determination of therapeutic heparin in human plasma via the measurement of Factor IIa (thrombin) activity.
ACTICHROME® Heparin (Anti-FXa), Activity Assay REF: 832 is an amidolytic chromogenic assay intended for the quantitative determination of therapeutic heparin in human plasma via the measurement of Factor Xa activity.

IMUCLONE™ Platelet Factor 4 ELISA REF: 634 is an enzyme-linked immunosorbent assay for measuring human Platelet Factor 4 in platelet depleted plasma, or in any biological fluid where Platelet Factor 4 may be present.

Antiphospholipid Syndrome
DVVtest® REF: 810 | REF: 825 is a dilute Russell’s Viper Venom Time (dRVVT) test intended for the determination of Lupus Anticoagulants (LA) in human plasma.

DVVconfirm® REF 815 is the high phospholipid containing coagulation reagent to be used in conjunction with DVVtest to confirm the presence of Lupus Anticoagulants (LA) in human plasma.

Abnormal Control (REF 816A) and LAtrol™ Normal Control (REF 816N) plasmas have been developed for use as part of daily quality control procedures for Lupus Anticoagulant (LA) testing.

Clinical studies show that a dilute prothrombin time test is an effective LA coagulation assay and can identify LA that are not detected by other tests such as a lupus-sensitive APTT and a dilute Russell’s Viper Venom test.
ACTICLOT® dPT™ Dilute Prothrombin Time Test REF: 824  is a fully integrated dilute prothrombin time test for screening and confirming the presence of phospholipid-dependent LA autoantibodies.

Bleeding Profiles
QuikCoag® APTT-EA  (Ellagic Acid) reagent is an in vitro diagnostic assay intended for use in determining activated partial thromboplastin time (APTT) and coagulationfactor assays that are based on a modified APTT.

QuikCoag® PT-HS  is an in vitro diagnostic assay intended for use in performing the one stage prothrombin time (PT) test and assays which are based on a modified prothrombin time.

QuikCoag® Fibrinogen is an in vitro diagnostic assay intended for quantitative determination of fibrinogen in plasma.

QuikCoag® Thrombin Time is a thrombin reagent (bovine) for use in the determination of the Thrombin Time (TT) in human plasma.

QuikCoag® Calcium Chloride is a reagent for use in the in vitro determination of prothrombin time (PT) test, activated partial thromboplastin time (APTT) and recalcification (plasma clotting) time, as well as various coagulation factor assays.

QuikCoag® Imidazole Buffer is intended for use in conjunction with QuikCoag Fibrinogen. It is used to dilute the plasma samples prior to doing the fibrinogen testing.

QuikCoag® Controls  are intended for use for quality assurance of in vitro diagnostic coagulation tests.
The controls are suitable for use in the one-stage prothrombin time (PT) test and in the activated partial thromboplastin time (APTT) test. Controls are available at three levels thromboplastin time (APTT) test. Controls are available at three levels

Cancer Prognosis
FEMTELLE™ uPA/PAI-1 ELISA REF: 899 is intended for the quantitative measurement of human Urokinase-type Plasminogen Activator (uPA) and human Plasminogen Activator Inhibitor Type-1 (PAI-1) in detergent extracts of breast tumor tissue. uPA and PAI-1 are clinically validated independent prognostic markers in breast cancer and have reached the highest Level of Evidence (LoE-1) according to the “Tumor Marker Utility System”.

Von Willebrand Disease
IMUBIND® vWF Activity ELISA REF: 885 is a quantitative direct enzyme-linked immunosorbent assay (ELISA) for the detection of von Willebrand Factor (vWF) activity in citrated human plasma.

D-Dimer
DIMERTEST® Latex is an immunoagglutination assay for the rapid qualitative or semi-quantitative evaluation of derivatives of cross-linked fibrin degradation products (XL-FDP) circulating in human plasma. During blood coagulation, fibrinogen is converted to fibrin monomers by thrombin, and these fibrin monomers polymerize to form a soluble gel of non-cross-linked fibrin. This fibrin gel is then converted to cross-linked fibrin by factor XIIIa to form an insoluble fibrin clot.

Thrombotic Risk Markers
For individuals with a documented thrombotic event and a family history of thrombosis, testing coagulation factors is crucial for diagnosing the condition. Deficiencies of natural anticoagulants Antithrombin III, Protein C, Protein S, and factor mutations such as Activated Protein C Resistance may lead to venous thrombosis: Superficial Venous thrombosis (SVT), Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE). Specific coagulation factors released from the vascular endothelium, Thrombomodulin and Tissue Factor Pathway Inhibitor offer information about endothelial dysfuncti on. When hemostasis is disrupted because thrombi are not degraded, levels of Plasminogen and Plasminogen Activator Inhibitor Type 1 (PAI-1) may provide information to the state of the patient. The mechanisms of thrombosis in cancer patients involve a complex interacti on between the tumor cell, the patient, and the hemostatic system. Tumors may activate coagulation by their expression of Tissue Factor.

ACTICHROME® TF REF: 846 is a chromogenic assay intended for the measurement of human Tissue Factor procoagulant activity in human plasma and cell lysates.

ACTICHROME® TFPI REF: 848  is a chromogenic assay intended for the measurement of Tissue Factor Pathway Inhibitor (TFPI) activity in human plasma where TFPI exhibits an inhibitory effect on the Tissue Factor/FVIIa complex. TFPI circulates in human plasma as complexes with LDL, HDL and VLDL and
can be found in several forms: a 36,000 D molecule, a 43,000 D molecule and as truncated moieties. Approximately 10% of the total amount of TFPI is carried by platelets, which release TFPI once they are activated by thrombin. At the site of a wound, where platelets aggregate, elevated levels of TFPI are present.

ACTICHROME® PLG REF: 851 is intended for the measurement of plasminogen in human plasma.

ACTICHROME® AT-III REF: 838 is an amidolytic chromogenic assay intended for the quantitative determination of antithrombin III in human plasma. Antithrombin III (AT-III) is an inhibitor of plasma serine proteases, including thrombin. AT-III levels of 30-60% of normal may be observed in patients with hereditary AT-III deficiency.

ACTICLOT® Protein C Resistance REF 840 is a plasma based functional assay for the determination of resistance to activated protein C caused by the Factor V Leiden mutation (FV:Q506).

ACTICLOT® Protein S REF: 843L is a functional clotting assay intended for the quantitative determination of Protein S activity in human plasma.

ACTICLOT® C REF ACC-45 is a functional clotting assay intended for the quantitative determination of Protein C activity in human plasma.

IMUBIND® Tissue PAI-1 ELISA REF: 821 is an enzyme-linked immunosorbent assay for the quantitative measurement of human Plasminogen

IMUBIND® Plasma PAI-1 ELISA REF 822 is an enzymelinked immunosorbent assay for the quantitative measurement of human Plasminogen Activator Inhibitor Type-1 (PAI-1) antigen in plasma.

IMUBIND® Thrombomodulin ELISA REF: 837 is an enzyme linked immunosorbent assay for the measurement of thrombomodulin in human plasma, serum and cell culture supernatants.

IMUBIND® Tissue Factor ELISA REF: 845  is intended for the measurement of human tissue factor (TF, thromboplastin, factor III) in human plasma, tumor tissue extracts and cell culture supernatants (e.g. LPS stimulated monocytes).

IMUBIND® uPA ELISA REF 894 is an enzyme-linked immunoassay for the quantitative determination of human urokinase-type plasminogen activator (uPA) in tissue extracts, plasma and cell culture supernatants.

IMUCLONE™ PAP ELISA REF: 603 is intended for the measurement of plasmin/alpha-2-antiplasmin (PAP) complexes in human plasma. The assay measures only PAP complexes.

IMUCLONE™ FPA ELISA REF: 635 is a competitive enzyme-linked immunosorbent assay (CELIA) for measuring human (FPA) on bentonite adsorbed human plasma or in any fluid where FPA may be present.

IMUCLONE™ Free Protein S ELISA REF: 842 is an enzyme-linked immunosorbent assay for measuring human Free Protein S (the activated Protein C cofactor) in plasma or any biological fluid where Free Protein S may be present.

IMUCLONE™ Total TAFI ELISA REF: 873 is an in vitro assay for the measurement of TAFI antigen in human plasma, or in any fluid where TAFI may be present.

SPECTROLYSE® PAI-1 REF: 10120 is intended for the quantitative determination of Plasminogen Activator Inhibitor Type-1 (PAI-1) activity in human plasma.

Thrombotic Thrombocytopenia Purpura
Thrombotic Thrombocytopenia Purpura (TTP) is a severe, occlusive, microvascular “thrombotic microangiopathy” characterized by low platelet count, microvascular thrombi, red cell fragmentation, central nervous system disorders and renal complications. ADAMTS13, also known as von Willebrand Factor (vWF) cleaving protease, is a zinc metalloproteinase that cleaves ultra large (UL) vWF multimers within the A2 region of vWF. The UL-vWF multimers bind to receptors on platelets inducing platelet aggregation and formation of intravascular microthrombi. Studies have shown that low levels of ADAMTS13 activity are strongly associated with a diagnosis of TTP. Assessing the ADAMTS13 protein levels and the presence of ADAMTS13 autoantibodies presents a comprehensive overview of the patient, identifying the patient’s condition as congenital versus acquired TTP.

ACTIFLUOR™ ADAMTS13 Activity Assay REF: 812 is a fluorescence resonance energy transfer (FRET) assay for the measurement of ADAMTS13 in human plasma. ADAMTS13, also known as von Willebrand Factor (vWF) cleaving protease, is a zinc metalloproteinase that cleaves ultra large vWF multimers (UL-vWF) at the Tyr(1605)-Met(1606) bond located in the A2 region of vWF.

IMUBIND® ADAMTS13 ELISA REF: 813 is intended for the measurement of ADAMTS13 protein in human plasma. ADAMTS13, also known as von Willebrand Factor (vWF) cleaving protease, is a zinc metalloproteinase that cleaves ultra large vWF multimers (UL-vWF) at the Tyr(1605) Met(1606) bond located in the A2 region of vWF.

IMUBIND® ADAMTS13 Autoantibody ELISA REF: 814 is intended for the measurement of ADAMTS13 IgG autoantibodies in human plasma. ADAMTS13, also known as von Willebrand Factor (vWF) cleaving protease, is a zinc metalloproteinase that cleaves ultra large vWF multimers (UL-vWF) at the Tyr(1605) Met(1606) bond located in the A2 region of vWF.